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. 2021 Jul 15;50(3):1221–1240. doi: 10.1093/nar/gkab544

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Rp configuration confers greater stability than Sp in the presence of the 5′ exonuclease PDII. Percent full-length strand for (A) Ttr sense, (B) C5 siRNA sense, (C) Ttr antisense, and (D) C5 antisense strands incubated with 5′ exonuclease PDII as a function of time. In each experiment, the control dT₂₀ with a 5′ terminal stereo-random PS (dTxdT19) was tested.