TABLE 2.
Sensitivity of ELISAs for syphilis in comparison with the IgM specific immunofluorescence test (19S IgM FTA-ABS)a
| Trade name (company) | Trepanostika (Organon) | ICE Syphilis (Murex) | Enzygnost Syphilis (Behring) | Pathozyme Syphilis Competition (Omega) | Bioelisa Syphilis (Biokit) | Trep-Chek (Phoenix) | TmpA-ELISA (Eurodiagnostica) | Captia Syphilis G (Trinity) | Captia Syphilis M (Mercia) | 19S IgM FTA-ABS |
|---|---|---|---|---|---|---|---|---|---|---|
| No. nonreactive/total no. | 12/52 | 13/52 | 16/52 | 16/52 | 17/41 | 15/41 | 16/31 | 24/31 | 7/52 | 5/52 |
| Sensitivity (%) | 76.9 | 75.0 | 69.2 | 69.2 | 67.3 | 63.4 | 48.5 | 22.6 | 86.5 | 90.4 |
| Sensitivity (95% confidence interval) | 63.2–87.5 | 61.1–86.0 | 54.9–81.3 | 54.9–81.3 | 52.9–79.7 | 46.9–77.9 | 30.2–66.9 | 9.6–41.1 | 74.2–94.4 | 79.0–96.8 |
a
Comparative evaluation was performed with 52 sera from patients with primary syphilis, all nonreactive in the MHA-TP test.