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. 2022 Feb 8;13:801915. doi: 10.3389/fimmu.2022.801915

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Copyright © 2022 Beaudoin, Bartas, Volná, Pečinka and Blundell

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural characterization of ORF2b and ORF-Sh. Full-length ORF2b (cyan) aligned with one protomer of the HMPV P oligomerization domain (green) fixed in a bilayer membrane (gray) is depicted (A). ORF-Sh (cyan) aligned to the mouse early growth response protein 1 (EGR1) (PDB: 1p47) (green), which is a homolog of transcriptional repressor CTCF, bound to DNA (grey) is shown (B). Basic residues in the ORF-Sh protein are shown as dark blue sticks (B).