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. 2022 Feb 8;9:754909. doi: 10.3389/fcvm.2022.754909

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Copyright © 2022 Chang, Lin, Luo, Lee and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The comparison between higher ECG-age and lower ECG-age for outcomes of interest in validation set. The plots display three groups, with ECG-age more than 7 years greater than the chronological age (denoted by: ECG-age –Age >7, red columnar) those with ECG-age within a range of 7 years from their chronological age (denoted by: ECG-age –Age-7 to 7, blue columnar); and, those with ECG-age more than 7 years smaller than the chronological age (denoted by: ECG-age –Age <7, green columnar). X-axis is cumulative incidence and y axis is year. We can find red columnar is obvious with high hazard ratio on all outcomes of interest with statistics significant. Green columnar demonstrated opposite effect on all outcomes of interest.