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. 2022 Feb 8;12:781820. doi: 10.3389/fonc.2022.781820

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Copyright © 2022 Yang, Hu, Li, Luo, Liu and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical application pattern of liquid biopsy in patients with hepatocellular carcinoma. Tumor composition analyses, such as circulating tumor cells, circulating tumor DNA, and exosomes, are released by tumors to the bloodstream. During the various treatments such as surgery, transcatheter arterial chemoembolization (TACE), radiofrequency ablation (RFA), and targeting molecular treatment, liquid biopsy can be used for diagnosis, prognosis, and progress monitoring of HCC patients. NGS, next-generation sequencing; MRD, minimal/molecular residual disease. Figure 1 created in BioRender (https://biorender.com/).