Table 2.
Significant PVAT gene expression changes
| Abbreviation | Fold change (array) | Fold change (rtPCR) avg (SE) |
|
|---|---|---|---|
| Adipogenesis-related genes | |||
| Up-regulated | |||
| Dickkopf1 homolog 1 | Dkk1 | 4.234 | |
| Insulin receptor substrate 2 | Irs2 | 1.825 | 2.03 (0.69) |
| Kruppel-like factor 2 | Klf2 | 1.766 | |
| Vitamin D receptor | Vdr | 1.656 | |
| Jun oncogene | Jun | 1.566 | |
| Down-regulated | |||
| GATA binding protein 3 | Gata3 | 0.051 | |
| Bone morphogenetic protein 7 | Bmp7 | 0.172 | 0.56 (0.07) |
| Wingless-related MMTV integration site 1 | Wnt1 | 0.407 | 0.70 (0.17) |
| E2F transcription factor 1 | E2f1 | 0.413 | |
| Nuclear receptor subfamily 0, group B, member 2 | Nr0b2 | 0.425 | |
| Rous sarcoma oncogene | Src | 0.480 | |
| Cyclin-dependent kinase 1b | Cdkn1b | 0.491 | |
| Nuclear respiratory factor 1 | Nrf1 | 0.511 | |
| CAMP responsive element binding protein 1 | Creb1 | 0.554 | |
| Early growth response 2 | Egr2 | 0.560 | |
| Axin 1 | Axin1 | 0.569 | |
| Wingless-related MMTV integration site 5B | Wnt5b | 0.596 | |
| TSC22 domain family, member 3 | Tsc22d3 | 0.641 | |
| Runt-related transcription factor 1 | Runx1t1 | 0.647 | |
| Inflammation-related genes | |||
| Interleukin-6 | IL-6 | ND | 1.48 (0.29) |
| Monocyte chemoattractant protein-1 | Mcp-1 | ND | 1.28 (0.15) |
Listed are those genes in the array analysis which were up-regulated (fold change >1.5 fold) or down-regulated (fold change <0.666) using pooled RNA samples. Also listed are fold changes of selected genes as determined by rtPCR using individual RNA samples. ND: not determined.