Fig. 2. MEG3 silencing inhibits cell viability and metastasis in SCLC. (A) The expression of MEG3 after transfection of sh-MEG3/NC or pcDNA3.1-MEG3/NC into SCLC cells (NCI-H69 and NCI-H446) was detected by qRT-PCR. ^***p<0.001 vs. the pcDNA3.1-NC group, ^###p<0.001 vs. the sh-NC group. (B) The viability of SCLC cells transfected with sh-MEG3/NC was measured by MTT assay. (C) The migration of SCLC cells transfected with sh-MEG3/NC was measured by transwell migration assay. (D) The invasion of SCLC cells transfected with sh-MEG3/NC was measured by transwell invasion assay. ^*p<0.05, ^**p<0.01 vs. the sh-NC group. SCLC, small-cell lung cancer.