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. 2022 Feb 21;12:2866. doi: 10.1038/s41598-022-06692-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between animal gut microbiota components and BAs. The color is according to the Pearson correlation coefficients; positive correlations are shown in red, while negative correlations are depicted in blue. The color intensity and the size of the circle are proportional to the correlation values. In addition, a significant correlation was highlighted by a white asterisk in the centre of each circle (p ≤ 0.001). BA and bacterial genus correlation profiles were clustered using a hierarchical clustering approach, using the profile Pearson correlation value as a similarity measure and Ward’s linkage method. The obtained clusters were represented by dendrograms at the top and left margins of the correlogram. Within each cluster, both BAs and bacterial genera were coloured according to the colour legend in the top right of the figure to highlight the significantly most abundant genus or BA in a specific animal species (see Supplementary Material Figs. S4 and S5).