Figure 3.

AdipoRon has no effects on glucose metabolism in FGF21 KO mice.A, diagram of the 10-day AdipoRon treatment regimen. Briefly, FGF21 KO mice fed the HFD for 4 weeks were subcutaneously injected with DMSO or AdipoRon (5 mg kg⁻¹ BW per day) for the last 10 days of the HFD feeding period. B and C, BW and food intake. D, time course of blood glucose and the GIR during clamp. E, endogenous glucose production (EGP) during basal infusion and clamp. F, whole-body glucose disposal. G, metabolic flux analysis in skeletal muscle (gastrocnemius and soleus). Data are presented as the mean ± SEM. BW, body weight; DMSO, dimethyl sulfoxide; FGF21, fibroblast growth factor 21; GIR, glucose infusion rate; HFD, high-fat diet.