Figure 6.

AdipoRon treatment for 20 days reduced whole-body EE in mice fed the HFD.A, time course of VCO₂. B, CO₂ production in dark and light hours. C, total CO₂ production. D, time course of O₂ consumption. E, O₂ consumption in dark and light hours. F, total O₂ consumption. G, time course of the RER. H, RER in dark and light hours. I, total RER. J, time course of EE. K, EE in dark and light hours. L, total EE. M, time course of physical activity. N, physical activity in dark and light hours. O, total activity. M, time course of EE. N, EE in dark and light hours. O, total EE. P, time course of food intake. Q, food intake in dark and light hours. R, total food intake. S, water intake in dark and light hours. T, total water intake. U, fat mass. V, fat percentage. W, lean mass. Data are presented as the mean ± SEM. ∗p < 0.05 and ∗∗p < 0.01. EE, energy expenditure; HFD, high-fat diet; RER, respiratory exchange rate; VCO₂, whole-body-adjusted carbon dioxide production.