Fig. 8. Diagram of the proposed mechanism and function of circNEIL3 in lung adenocarcinoma radiotherapy.

circNEIL3 exerts its function as a ceRNA by directly binding to miR-1184, thereby abrogating the endogenous inhibitory effect of miR-1184 on the target gene PIF1, and inducing significant DNA damage, which in turn triggers AIM2 inflammasome activation to induce pyroptosis, ultimately affecting survival in lung cancer radiotherapy.