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. 2020 Oct 18;117(11):2365–2376. doi: 10.1093/cvr/cvaa298

Figure 2.

Figure 2

LC diets mitigate pressure overload-induced heart failure. Cardiac function and heart failure were evaluated 4 weeks after the randomization into the indicated diet. (A) Representative pictures of M-mode echocardiography. Transverse scale bar, 100 ms. Vertical scale bar, 0.5 cm. (B) Ejection fraction, as evaluated by M-mode echocardiography (n = 7–8). (C) LVEDP, as evaluated by haemodynamic study (n = 4–6). (D) Lung weight normalized by TL (n = 7–8). (E) Liver weight normalized by TL (n = 7–8). Kruskal–Wallis test with the Dunn’s multiple comparison test was performed. (F–G) LC diet attenuates hypertrophic signalling pathways in response to pressure overload. Representative immunoblots showing the hypertrophic signalling pathways (F) and associated densitometry analyses, normalized by α-sarcomeric actinin (n = 6) (G). One-way ANOVA followed by the Tukey’s post hoc analysis was used unless otherwise stated. Error bars indicate SEM. *P < 0.05, **P < 0.001.