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. 2022 Feb 8;13:819728. doi: 10.3389/fphar.2022.819728

FIGURE 1.

FIGURE 1

TMDCT can alleviate allergic inflammation in eosinophilic asthma BALB/c mice. (A) Experimental protocol for eosinophilic asthma induced by OVA and treatment administration. (B) Lung function experiments. Detection the Penh value when the methacholine concentration is 0, 6.25, 12.5, 25, 50 mg/ml respectively. Penh ratio (average Penh in the 5-minute interval with methacholine divided by the average Penh in the 5-minute interval with PBS). a, p < 0.05 vs. Control; aa, p < 0.01 vs. Control; aaa, p ≤ 0.001 vs. Control. b, p < 0.05 vs. TMDCT(H); bb, p < 0.01 vs. TMDCT(H); bbb, p ≤ 0.001 vs. TMDCT(H). c, p < 0.05 vs. TMDCT(M); cc, p < 0.01 vs. TMDCT(M); ccc, p ≤ 0.001 vs. TMDCT(M). d, p < 0.05 vs. TMDCT(L); dd, p < 0.01 vs. TMDCT(L); ddd, p ≤ 0.001 vs. TMDCT(L). (C) Left: HE staining of lung tissues; Right: Inflammatory score results. (D) Left: PAS staining of lung tissues; Right: Total lung inflammation was defined as the average of the peribronchial and perivascular inflammation scores. (E) Detection if specific OVA-IgE in serum; eosinophils count in BALF; detection of cytokines IL-4, IL-5, IL-13. All the values are expressed as mean +/- SEM. n = 4-5 animals per group.