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. 2022 Feb 8;13:819728. doi: 10.3389/fphar.2022.819728

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Copyright © 2022 Zhou, Zhao, Wang, Zhao, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Untarget plasma metabolism detection. (A) OPLS-DA analysis of LC/MS data in positive mode (left) and negative mode (right) from TMDCT(H) vs. Model. (B) Volcano map of differential metabolites in positive and negative mode. The metabolites with FC > 1.5, p value <0.05 are indicated by rose red, satisfying FC < 0.67, p value < 0.05 are shown in blue. (C) Hierarchical clustering heat map in positive mode (left) and negative mode (right). (D) Enriched KEGG pathways based on significant different metabolites between TMDCT(H) group and Model group. n =7 animals per group.