Table 2.
Comparison of APOE genotypes and alleles frequency between the control group and the case group.
| Variables | Control | T2DM | CAD | T2DM+CAD | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| APOE genotypes | n | n | OR (95% CI) | OR (95% CI) a | p a | n | OR (95% CI) | OR (95% CI) a | p a | n | OR (95% CI) | OR (95% CI) a | p a |
| ϵ2/ϵ2 | 6 | 3 | 1.13 (0.28-4.58) | 1.19 (0.29-4.83) | 0.813 | 1 | 0.24 (0.03-2.01) | 0.22 (0.03-1.82) | 0.158 | 0 | – | – | – |
| ϵ2/ϵ3 | 87 | 47 | 1.22 (0.82-1.82) | 1.22 (0.82-1.82) | 0.334 | 52 | 0.86 (0.59-1.26) | 0.86 (0.59-1.25) | 0.427 | 27 | 0.91 (0.57-1.46) | 0.90 (0.56-1.46) | 0.673 |
| ϵ2/ϵ4 | 6 | 2 | 0.75 (0.15-3.78) | 0.77 (0.15-3.86) | 0.748 | 3 | 0.72 (0.18-2.91) | 0.69 (0.17-2.81) | 0.605 | 4 | 1.96 (0.54-7.03) | 1.84 (0.5-6.72) | 0.357 |
| ϵ3/ϵ3 | 387 | 171 | Reference | Reference | – | 268 | Reference | Reference | – | 132 | Reference | Reference | – |
| ϵ3/ϵ4 | 58 | 39 | 1.52 (0.98-2.37) | 1.45 (0.93-2.27) | 0.102 | 75 | 1.87 (1.28-2.72) | 1.90 (1.30-2.77) | 0.001 | 39 | 1.97 (1.26-3.1) | 1.95 (1.24-3.08) | 0.004 |
| ϵ4/ϵ4 | 1 | 2 | 4.53 (0.41-50.25) | 5.18 (0.46-57.94) | 0.182 | 2 | 2.89 (0.26-32.01) | 2.23 (0.20-24.85) | 0.515 | 2 | 5.86 (0.53-65.19) | 6.27 (0.56-70.17) | 0.136 |
| Alleles | |||||||||||||
| ϵ2 | 105 | 55 | 1.13 (0.80-1.59) | 1.13 (0.80-1.60) | 0.484 | 57 | 0.75 (0.54-1.06) | 0.74 (0.53-1.04) | 0.081 | 31 | 0.82 (0.54-1.25) | 0.82 (0.53-1.25) | 0.346 |
| ϵ3 | 919 | 428 | Reference | Reference | – | 663 | Reference | Reference | – | 330 | Reference | Reference | – |
| ϵ4 | 66 | 45 | 1.46 (0.99-2.18) | 1.42 (0.96-2.12) | 0.082 | 82 | 1.72 (1.23-2.42) | 1.72 (1.22-2.42) | 0.002 | 47 | 1.98 (1.34-2.94) | 1.97 (1.32-2.93) | < 0.001 |
a
Adjusted for age and sex. Bold values denote statistical significance at the p < 0.05 level.