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. 2022 Feb 8;10:800650. doi: 10.3389/fcell.2022.800650

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Copyright © 2022 Wei, Deng, Dong, Xie, Zhang, Wang, Zhang, Na and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two major clusters were identified in heterogeneously expressed FRGs. (A) Heatmap showing heterogeneously expressed FRGs across IRI samples. The color bar showed the expression level of genes. (B) Spearman correlation analysis revealed two major clusters with genes in one cluster opposite to the other cluster. The inset displayed the top 10 correlated genes in each cluster. The color bar showed the range of spearman correlation r. (C) Co-expression analysis of the top 10 correlated genes in each cluster with genes involved in inflammasome and immune pathways. Gray lines indicated negative correlation while green lines indicated positive correlation between genes.