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. 2022 Feb 8;10:800650. doi: 10.3389/fcell.2022.800650

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Copyright © 2022 Wei, Deng, Dong, Xie, Zhang, Wang, Zhang, Na and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of the model with involved function, immune cell infiltration, and ferroptosis. (A–C) GSEA showing the involved function of high-risk and low-risk groups in terms of the DGF-related pathway, immune, and metabolism. Terms with p < 0.05 and FDR q < 0.25 were considered statistically significant. (D) Differences of immune cell infiltration between low-risk and high-risk groups, estimated by the xCell algorithm. (E) Gene expression of key ferroptosis markers, namely, GPX4 and PTGS2 between risk groups. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.