Table 3.
Cumulative number of patients experiencing each symptom.
| Age at onset and cumulative numbers (%) of each symptom |
At diagnosis (0–84 months) | ||||
|---|---|---|---|---|---|
| 0–1 month | ~2 months | ~3 months | ≥4 months | ||
| Abnormal hair (n = 69) | 20 (29) | 26 (38) | 34 (49) | 42 (61) | 68 (99) |
| Hypothermia (n = 53) | 8 (15) | 12 (23) | 13 (25) | 14 (26) | 25 (47) |
| Muscle weakness (n = 37) | 1 (3) | 1 (3) | 3 (8) | 11 (29) | 38 (100) |
| Hypopigmented skin (n = 39) | 4 (10) | 5 (13) | 12 (31) | 15 (38) | 35 (90) |
| Seizure (n = 66) | 2 (3) | 11 (17) | 24 (36) | 38 (58) | 64 (97) |
| Developmental retardation (n = 62) | 4 (6) | 8 (13) | 14 (23) | 32 (52) | 57 (92) |
| Feeding difficulties (n = 17) | 3 (17) | 8 (44) | 12 (67) | 16 (89) | 16 (89) |
| Hypotonia (n = 15) | 2 (13) | 4 (25) | 7 (44) | 13 (81) | 13 (81) |
| Jaundice (n = 67) | 16 (24) | 16 (24) | 16 (24) | 16 (24) | 16 (24) |
| Loose skin (n = 9) | 1 (11) | 1 (11) | 1 (11) | 2 (22) | 9 (100) |