Table 7.
Summary of preclinical studies on CAR-T cells strategies counteracting the immunosuppressive effect of MDSCs.
| Targeted antigen | Expressed genes | Co-administered agent | Type of cancer | Reference |
|---|---|---|---|---|
| GD2 | – | ATRA | Osteosarcoma | (243) |
| GD2MSLNEGFRvIII | – | GO | Solid tumors | (244) |
| EGFRvIII | – | Olaparib | Breast cancer | (245) |
| CAIX | – | Sunitinib | Metastatic renal caner | (246) |
| EGFRvIII | – | Poly I:C | Breast cancerColon cancer | (247) |
| GD2 | – | NKG2D.ζ CAR-NK | Neuroblastoma | (248) |
| MUC1 | TR2.4-1BB | – | Breast cancer | (249) |
| HER2 | TR2.4-1BB | – | Breast cancer |