Table. Hospitalizations of Children Aged 5 to 11 Years by Viral Infection Across 11 Statesa.
| Variable | No. (95% CI) | |||
|---|---|---|---|---|
| January-March 2021 | January-March 2017 | |||
| MIS-C | SARS-CoV-2 without MIS-C | Influenza | RSV | |
| Total, No. | 379 | 343 | 1134 | 413 |
| Total, No. per 100 000 kids | 5.7 | 5.1 | 17.0 | 6.2 |
| Demographic characteristics | ||||
| Age, median (IQR), y | 8 (7-10) | 8 (7-10) | 7 (6-9)b | 6 (5-8)b |
| Proportion of female children | 0.406 (0.357-0.456) | 0.458 (0.405-0.511) | 0.415 (0.387-0.444) | 0.525 (0.477-0.574)b |
| Proportion of male children | 0.594 (0.544-0.643) | 0.542 (0.489-0.595) | 0.585 (0.556-0.613) | 0.475 (0.426-0.523)b |
| Proportion of each race and ethnicity | ||||
| Asian or Pacific Islander | 0.029 (0.009-0.049) | 0.015 (0-0.029) | 0.026 (0.016-0.035) | 0.011 (0-0.022) |
| Black | 0.101 (0.065-0.136) | 0.158 (0.114-0.202)e | 0.105 (0.086-0.124) | 0.129 (0.094-0.164) |
| Hispanic | 0.381 (0.324-0.439) | 0.239 (0.188-0.290)b | 0.243 (0.216-0.270)b | 0.090 (0.060-0.120)b |
| Non-Hispanic White | 0.432 (0.373-0.490) | 0.551 (0.492-0.611)b | 0.579 (0.548-0.610)b | 0.716 (0.669-0.763)b |
| Otherc | 0.058 (0.030-0.085) | 0.037 (0.014-0.059) | 0.047 (0.034-0.060) | 0.053 (0.030-0.077) |
| Outcomes | ||||
| Inpatient death | <11d | <11d | <11d | <11d |
| No. of body systems affected | 1.913 (1.775-2.050) | 0.866 (0.763-0.969)b | 0.981 (0.930-1.032)b | 1.266 (1.185-1.348)b |
| Complications | ||||
| Cardiovascular | 0.298 (0.252-0.344) | 0.032 (0.013-0.051)b | 0.020 (0.012-0.028)b | 0.029 (0.013-0.045)b |
| Myocarditis/pericarditis | 0.111 (.079-.143) | <11d | <11d | <11d |
| Respiratory | 0.282 (0.237-0.328) | 0.210 (0.167-0.253)e | 0.306 (0.279-0.333) | 0.758 (0.716-0.799)b |
| Neurologic | 0.050 (0.028-0.072) | 0.096 (0.065-0.128)e | 0.063 (0.048-0.077) | 0.063 (0.039-0.086) |
| Hematologic | 0.554 (0.504-0.604) | 0.134 (0.098-0.170)b | 0.099 (0.081-0.116)b | 0.126 (0.094-0.158)b |
| Sepsis | 0.108 (0.077-0.140) | 0.050 (0.026-0.073)b | 0.034 (0.023-0.044)b | 0.065 (0.041-0.089)b |
| Shock | 0.142 (0.107-0.178) | <11d | 0.017 (0.009-0.024)b | 0.031 (0.015-0.048)b |
| Kidney failure | 0.219 (0.177-0.261) | 0.067 (0.040-0.094)b | 0.036 (0.025-0.047)b | 0.034 (0.016-0.051)b |
| Gastrointestinal | 0.472 (0.422-0.523) | 0.312 (0.263-0.361)b | 0.364 (0.336-0.392)b | 0.252 (0.210-0.294)b |
| Musculoskeletal | 0.037 (0.018-0.056) | <11d | 0.095 (0.078-0.112)b | <11d |
| Utilization, median (IQR), No. | ||||
| Length of stay, d | 5 (3-7) | 3 (2-6)b | 2 (1-4)b | 3 (2-6)b |
| Hospital costs, $ | 23 585 (15 040-39 122) | 10 399 (5314-23 546)b | 5200 (2959-9449)b | 9080 (4648-21 075)b |
| Hospital charges, $ | 78 208 (52 896-114 562) | 34 946 (20 231-73 689)b | 17 696 (10 579-31 032)b | 29 166 (15 335-63 780)b |
Abbreviations: MIS-C, multisystem inflammatory syndrome for children; RSV, respiratory syncytial virus.
a
Includes data from the first quarter of 2021 (January-March) from 1333 hospitals in Colorado, Georgia, Iowa, Kentucky, Michigan, Missouri, Mississippi, New Jersey, Ohio, Washington, and Wisconsin. Complications are defined in the eMethods in the Supplement.
b
Significantly different compared with MIS-C: P < .01.
c
Other includes Native American or other as reported by the Healthcare Cost and Utilization Project.
d
Values masked owing to a patient number less than 11.
e
Significantly different compared with MIS-C: P < .05.