Discrepancies in numbers reflect missing data for each outcome measure. As the number of conditions increased, midlife age advanced, as assessed by pace of aging (0.38 [95% CI, 0.29-0.47] SD units), gait speed (0.27 [95% CI, 0.17-0.36] SD units), BrainAGE score (0.14 [95% CI, 0.04-0.23] SD units), and facial age (0.33 [95% CI, 0.24-0.42] SD units).