Table 3.

Mathematical Modeling of L-triiodothyronine- and Poly-Zinc-Liothyronine-Derived Triiodothyronine

Time (hours)	Mixed effects			PW mixed effects		AUC
	LT3	PZL	p	LT3-PZL	p	LT3	PZL	p
1	140	122	0.15
2	298	208	0.05
3	304	230	0.07
4	265	221	0.12
6	205	221	0.33
8	178	203	0.10
12	141	165	0.04
18	129	147	0.06
24	122	143	0.02
36	102	110	0.08
46	100	102	0.50
1–2				73	0.12
2–3				−17	0.55
3–4				−55	0.04
4–12				−6.35	0.06
12–46				0.9	0.03
0–3						704	554	0.14
3–12						1775	1828	0.66
12–24						1559	1808	0.05
24–48						2349	2574	0.05
0–48						6387	6765	0.24

Data shown for T3 levels in ng/dL; AUC is ng·hour/dL; LT3-PZL is the difference between the fixed effect of time under LT3 and PZL; for the PW mixed-effects model the effect of baseline response was 0.6 (SE = 0.07); the linear fixed effect of time under the PZL between 1 and 2 hours was 85.1 (SE = 26.4), between 2 and 3 hours was 22.6 (SE = 14.1), between 3 and 4 hours was −0.59 (SE = 20.1), between 4 and 12 hours was −8.1 (SE = 2.3), and between 12 and 46 hours was −2.0 (SE = 0.4).

AUC, area under the curve; PB, placebo; PW, piecewise; SE, standard error; T3, triiodothyronine.