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. 2021 Apr 8;71(3):627–642. doi: 10.1136/gutjnl-2020-323585

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Efficacy of DAA combinations containing NS5A inhibitors and sofosbuvir against ED43 escape viruses. (A, B) For each DAA combination, concentrations of 5x-EC₅₀ of NS5A inhibitors were used in combination with either 1x- or 2x-EC₅₀ of sofosbuvir. (C, D) NGS analysis of complete ORF sequences of viruses after combination treatments. For details, see figure 5 legend. NGS, next-generation sequencing; ORF, open reading frame.