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Genotype–phenotype relationship for the three most important subtypes, types 1, 2 and 3. See text for further explanation. I Kr, rapidly activating delayed rectifier potassium current; I Kr, rapidly activating delayed rectifier potassium current; I Na, L, late sodium current; LQTS, long QT syndrome; ↓, decrease; ↑, increase; +, therapeutic effect size of β-blocker therapy.
