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. 2022 Feb 8;8:777961. doi: 10.3389/fmed.2021.777961

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Copyright © 2022 Tian, Ye, Yang, Cui, Zheng, Wu, Zhou, Lv, Qin, Qin, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sample clustering and classification for Enterotype analysis. According to the Jensen–Shannon distance of genus level, all the samples are clustered into the 3 types by the method of Manimozhiyan. Each of these 3 clusters are identifiable by the variation in the levels of 1 of 3 genera: Bacteroides (cluster 1), Prevotella (cluster 2), Alistipes and Ruminococcus (cluster 3). The histogram shows the distribution ratio of the control and STC groups in the 3 clusters.