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. 2022 Feb 7;18(1):2002083. doi: 10.1080/21645515.2021.2002083

Table 3.

Tolerability and systemic adverse effects experienced by Moderna vaccine recipients after second dose35.

  Individuals 18 to 64
  Individuals 65 and older
 
 
Mild
Severe (resulting in debilitating symptoms)
Mild
Severe (resulting in debilitating symptoms)
Tolerability (Local and immediate reactions)
Injection Site Pain 90.1% 4.6% 83.4% 2.7%
Erythema 9.0% 2.0% 7.4% 2.1%
Swelling 12.6% 1.7% 10.8% 1.9%
Systemic Reactions
Headache 62.8% 5.0% 46.4% 3.0%
Fatigue 67.6% 10.6% 58.4% 6.9%
Myalgia 61.3% 10.0% 46.9% 5.6%
Nausea 21.3% <0.1% 11.8% 0.3%
Fever 17.4% 1.6% 10.2% 0.5%