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. 2022 Feb 8;12:815654. doi: 10.3389/fonc.2022.815654

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Copyright © 2022 Wang, He, Xu, Xue, Zhu, Liu, Zhang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mechanism of action of PROTAC. (B) ALK signaling-mediated cycle operation. (C) Epigenetic alterations promote the development of ALK-positive ALCL. (D) Mechanism of ALK inhibition by HSP90.