TABLE 1.
Genetic, phenotypic, and serological properties of H. pylori isolates from 33 patients with gastritis and endoscopically defined gastroduodenal pathology and 15 asymptomatic H. pylori-infected subjects
| Clinical diagnosis | No. of patients | No. (%) of H. pylori isolates with the following genetic and phenotypic propertiesa:
|
No. (%) of serum samples with the following:
|
|||||
|---|---|---|---|---|---|---|---|---|
| vacA, ho | vacA, he | cagA positive (%) | Tox+ | Neutralizing activity | Anti-VacA IgGb | Anti-CagA IgG | ||
| Ulcer dyspepsia | 18 | 14 (77.8) | 4 (22.2) | 17 (94.4) | 9 (50.0) | 13 (72.2) | 13 (72.2) | 17 (94.4) |
| Nonulcer dyspepsia | 15 | 8 (53.3) | 7 (46.7) | 13 (86.7) | 7 (46.7) | 10 (66.7) | 10 (66.7) | 12 (80.0) |
| Asymptomatic, infected | 15 | 5 (33.3) | 10 (66.7) | 12 (80.0) | 7 (46.7) | 8 (53.3) | 8 (53.3) | 10 (66.7) |
a
Strains with homogeneous (ho) and heterogeneous (he) restriction pattern profiles for PCR-based amplification of the vacA gene and digestion with HaeIII are indicated (see Fig. 1a). Tox+, in vitro cytotoxin production.
b
IgG, immunoglobulin G.