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. 2022 Feb 21;10:5. doi: 10.1186/s40170-022-00282-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — scRNAseq analysis reveals the pathways that are altered in each cell type by hyperinsulinemia. A Heatmap showing Reactome pathways that are upregulated in PK-Ins1^-/-;Ins2^+/- mice when compared with PK-Ins1^-/-;Ins2^+/+ mice for each cell type. The intensity of color indicates the negative log₁₀ of adjusted p value. B Heatmap of Reactome pathways that are downregulated in PK-Ins1^-/-;Ins2^+/- mice when compared with PK-Ins1^-/-;Ins2^+/+ mice for each cell type. The intensity of color indicates the negative log₁₀ of adjusted p value. C Immunohistochemistry of phospho-Erk for PK-Ins1^-/-;Ins2^+/+ and PK-Ins1^-/-;Ins2^+/- pancreata. Scale bars: 0.1 mm. D The correlation of composite PanINs area with phospho-Erk positive area. *p < 0.05, **p < 0.01