Table 1.
Numbers of HCT in Europe 2020 by indication, donor type and stem cell source.
| Transplant activity 2020 | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of patients | ||||||||||||||||||
| Allogeneic | Autologous | Total | ||||||||||||||||
| Family | Unrelated | Allo | Auto | Total | ||||||||||||||
| HLA-id | Twin | Haplo ≥ 2MM | Other family | BM | BM+ | |||||||||||||
| BM | PBPC | Cord | all | BM | PBPC | BM | PBPC | Cord | BM | PBPC | cord | only | PBPC | cord | ||||
| Myeloid malignancies | 245 | 2413 | 9 | 8 | 291 | 1569 | 12 | 84 | 5 | 253 | 5209 | 119 | 0 | 224 | 0 | 10,217 | 224 | 10,441 |
| Acute myeloid leukemia | 167 | 1697 | 0 | 6 | 229 | 1117 | 9 | 67 | 4 | 143 | 3324 | 94 | 0 | 222 | 0 | 6857 | 222 | 7079 |
| 1st complete remission | 118 | 1124 | 0 | 3 | 131 | 583 | 6 | 36 | 3 | 94 | 1862 | 53 | 0 | 186 | 0 | 4013 | 186 | 4199 |
| Not 1st complete remission | 38 | 393 | 0 | 3 | 65 | 374 | 3 | 24 | 1 | 36 | 861 | 30 | 0 | 31 | 0 | 1828 | 31 | 1859 |
| AML therapy-related or myelodysplasia-related changes | 11 | 180 | 0 | 0 | 33 | 160 | 0 | 7 | 0 | 13 | 601 | 11 | 0 | 5 | 0 | 1016 | 5 | 1021 |
| Chronic myeloid leukemia | 9 | 106 | 1 | 0 | 7 | 40 | 0 | 4 | 0 | 15 | 171 | 1 | 0 | 0 | 0 | 354 | 0 | 354 |
| Chronic phase | 4 | 56 | 1 | 0 | 5 | 17 | 0 | 3 | 0 | 9 | 67 | 1 | 0 | 0 | 0 | 163 | 0 | 163 |
| Not chronic phase | 5 | 50 | 0 | 0 | 2 | 23 | 0 | 1 | 0 | 6 | 104 | 0 | 0 | 0 | 0 | 191 | 0 | 191 |
| MDS or MD/MPN overlap | 62 | 432 | 7 | 1 | 46 | 308 | 3 | 9 | 1 | 87 | 1231 | 23 | 0 | 0 | 0 | 2210 | 0 | 2210 |
| MPN | 7 | 178 | 1 | 1 | 9 | 104 | 0 | 4 | 0 | 8 | 483 | 1 | 0 | 2 | 0 | 796 | 2 | 798 |
| Lymphoid malignancies | 280 | 1252 | 4 | 11 | 199 | 924 | 9 | 48 | 3 | 200 | 2038 | 78 | 32 | 21,042 | 0 | 5046 | 21,074 | 26,120 |
| Acute lymphatic leukemia | 237 | 720 | 4 | 4 | 139 | 537 | 7 | 31 | 3 | 173 | 1106 | 63 | 0 | 54 | 0 | 3024 | 54 | 3078 |
| 1st complete remission | 132 | 498 | 3 | 1 | 68 | 274 | 3 | 16 | 3 | 81 | 739 | 31 | 0 | 51 | 0 | 1849 | 51 | 1900 |
| Not 1st complete remission | 105 | 222 | 1 | 3 | 71 | 263 | 4 | 15 | 0 | 92 | 367 | 32 | 0 | 3 | 0 | 1175 | 3 | 1178 |
| Chronic lymphocytic leukemia | 2 | 42 | 0 | 0 | 2 | 17 | 0 | 2 | 0 | 2 | 98 | 4 | 0 | 33 | 0 | 169 | 33 | 202 |
| Plasma cell disorders—MM | 1 | 88 | 0 | 5 | 8 | 21 | 0 | 1 | 0 | 1 | 134 | 0 | 11 | 12,354 | 0 | 259 | 12,365 | 12,624 |
| Plasma cell disorders—other | 0 | 7 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 1 | 17 | 0 | 0 | 401 | 0 | 30 | 401 | 431 |
| Hodgkin lymphoma | 12 | 100 | 0 | 0 | 17 | 129 | 1 | 3 | 0 | 2 | 108 | 3 | 9 | 2125 | 0 | 375 | 2134 | 2509 |
| Non-Hodgkin lymphoma | 28 | 295 | 0 | 2 | 32 | 216 | 1 | 11 | 0 | 21 | 575 | 8 | 12 | 6075 | 0 | 1189 | 6087 | 7276 |
| Solid tumors | 1 | 0 | 0 | 0 | 7 | 24 | 2 | 0 | 0 | 0 | 2 | 0 | 18 | 1667 | 1 | 36 | 1686 | 1722 |
| Neuroblastoma | 0 | 0 | 0 | 0 | 7 | 20 | 1 | 0 | 0 | 0 | 0 | 0 | 12 | 492 | 1 | 28 | 505 | 533 |
| Soft tissue sarcoma/Ewing | 1 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 278 | 0 | 4 | 281 | 285 |
| Germinal tumors | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 455 | 0 | 0 | 456 | 456 |
| Other solid tumors | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 0 | 2 | 442 | 0 | 4 | 444 | 448 |
| Non-malignant disorders | 586 | 267 | 21 | 4 | 119 | 207 | 58 | 47 | 2 | 370 | 469 | 63 | 4 | 315 | 0 | 2213 | 319 | 2532 |
| Bone marrow failure—SAA | 168 | 122 | 0 | 4 | 35 | 55 | 8 | 6 | 0 | 118 | 151 | 9 | 0 | 1 | 0 | 676 | 1 | 677 |
| Bone marrow failure—other | 43 | 21 | 1 | 0 | 14 | 22 | 10 | 6 | 0 | 51 | 53 | 5 | 0 | 0 | 0 | 226 | 0 | 226 |
| Thalassemia | 120 | 27 | 12 | 0 | 3 | 9 | 12 | 6 | 0 | 33 | 53 | 0 | 0 | 6 | 0 | 275 | 6 | 281 |
| Sickle cell disease | 107 | 56 | 5 | 0 | 18 | 11 | 5 | 1 | 0 | 15 | 6 | 0 | 0 | 1 | 0 | 224 | 1 | 225 |
| Primary immune deficiencies | 124 | 27 | 3 | 0 | 43 | 92 | 18 | 25 | 0 | 107 | 160 | 22 | 4 | 1 | 0 | 621 | 5 | 626 |
| Inh. disorders of Metabolism | 23 | 10 | 0 | 0 | 6 | 18 | 5 | 2 | 2 | 42 | 38 | 27 | 0 | 8 | 0 | 173 | 8 | 181 |
| Autoimmune disease—MS | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 226 | 0 | 1 | 226 | 227 |
| Autoimmune disease—SSC | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 49 | 0 | 1 | 49 | 50 |
| Autoimmune disease—other | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 | 8 | 0 | 0 | 23 | 0 | 16 | 23 | 39 |
| Others | 28 | 15 | 0 | 0 | 5 | 17 | 2 | 5 | 0 | 19 | 37 | 7 | 0 | 66 | 0 | 135 | 66 | 201 |
| Total patients | 1140 | 3947 | 34 | 23 | 621 | 2741 | 83 | 184 | 10 | 842 | 7755 | 267 | 54 | 23,314 | 1 | 17,647 | 23,369 | 41,016 |
| Re/additional transplants | 29 | 123 | 2 | 1 | 46 | 382 | 4 | 11 | 1 | 46 | 473 | 31 | 3 | 3196 | 0 | 1149 | 3199 | 4348 |
| Total transplants | 1169 | 4070 | 36 | 24 | 667 | 3123 | 87 | 195 | 11 | 888 | 8228 | 298 | 57 | 26,510 | 1 | 18,796 | 26,568 | 45,364 |