Figure 2.

Regional distribution of p‐α‐syn concentration in LBD and Control cases (pSyn/81A‐Syn1B ELISA). Levels of insoluble p‐α‐syn were measured by sandwich ELISA in eight brain regions from LBD (black circles) cases (A) and four brain regions from control (red triangles) and AD (blue diamonds) cases (B). The highest median levels of p‐α‐syn in LBD cases were in ACG, caudate, and amygdala. The LLQ for the ELISAs was 0.15 ng/mL or 9.99 ng/g wet wt tissue. All samples from control and AD cases were below the lower limit of quantification for p‐α‐syn except one control MFG sample and one control ACG sample. The α‐syn level in ACG was significantly higher in LBD compared with control cases. Data were analyzed with the two‐tailed Mann–Whitney test using a significance level of 0.05 and corrected for multiple comparisons with the Holm‐Bonferroni method. ⁵²