Table 1.
Baseline demographic and intraoperative characteristics.
| Total (N = 110) | |
|---|---|
| Age (years) (SD) | 69.2 (6.5) |
| Race (%) | |
| Black or African American | 10 (9.1) |
| Caucasian/White | 99 (90.0) |
| Not reported/declined | 1 (0.9) |
| Gender (male) (%) | 69 (62.7) |
| Height (cm) (Q1, Q3) | 171.9 (10.7) |
| Weight (kg) (SD) | 85.7 (18.8) |
| BMI (kg/m2) [Q1, Q3] | 28.6 [24.5, 32.0] |
| Years of education [Q1, Q3] | 16.0 [12.0, 18.0] |
| MMSE total score [Q1, Q3] | 29.0 [28.0, 29.0] |
| MMSE category (%) | |
| <20 | 1 (0.9) |
| 20–24 | 6 (5.5) |
| 25–30 | 103 (93.6) |
| Mean Baseline Cognitive Index (SD) | 0.074 (0.74) |
| Median baseline Aβ (MAD) | 360.1 (51.4) |
| Median baseline p‐tau (MAD) | 27.0 (6.2) |
| Median baseline p‐tau/Aβ (MAD) | 0.076 (0.018) |
| Median baseline tau (MAD) | 47.6 (8.2) |
| Median baseline tau/Aβ (MAD) | 0.135 (0.026) |
| APOE4 positive | 35 (32.4) |
| ASA physical status classification (%) | |
| 1 | 1 (0.9) |
| 2 | 23 (20.9) |
| 3 | 84 (76.4) |
| 4 | 2 (1.8) |
| Surgery type (%) | |
| Thoracic | 11 (10.0) |
| General | 31 (28.2) |
| Gynecologic | 2 (1.8) |
| Orthopedic | 21 (19.1) |
| Otolaryngology head and neck | 2 (1.8) |
| Plastic | 3 (2.7) |
| Urologic | 40 (36.4) |
| Nerve block type (%) | |
| None | 94 (85.5) |
| Peripheral nerve block | 15 (13.6) |
| Epidural block | 1 (0.9) |
| Surgery duration (minute) [Q1, Q3] | 140.0 [100.0, 199.0] |
| Case average BIS [Q1, Q3] 1 | 46.1 [41.9, 51.5] |
| Received inhaled anesthetic for >50% of case | 56 (50.9) |
| Case average aaMAC [Q1, Q3] 2 | 0.7 [0.7, 0.8] |
| aaMAC hours [Q1, Q3] 2 | 1.6 [1.3, 2.7] |
| Received intraoperative dexmedetomidine (%) | 13 (11.8) |
| Received intraoperative ketamine (%) | 23 (20.9) |
| Received intraoperative propofol >400 mg (%) | 55 (50.0) |
| Intraoperative propofol dose (mg) (Q1, Q3) 3 | 1357.0 [975.5, 2536.8] |
| Hospital LOS (days) [Q1, Q3] | 2.0 [1.0, 3.0] |
aaMAC, age‐adjusted minimum alveolar concentration for inhaled anesthetics; BIS, Bispectral Index (processed EEG value); LOS, length of stay; MAD, median absolute deviation; MMSE, Mini‐Mental State Examination; SD, standard deviation.
1
Among those who had BIS values for >50% of the case.
2
Among those who received inhaled anesthetic for >50% of the case.
3
Among those who received >400 mg intraoperative propofol.