| First Author, Publication Year (Ref) | Study Design | Size (n) | Spasticity Origin |
|---|---|---|---|
| Abbatemarco, 2020 (35) | Retrospective | 256 | Spinal (Multiple Sclerosis) |
| Barney, 2020 (8) | Prospective non-RCT | 32 | Cerebral (Cerebral Palsy) |
| Bayhan, 2016 (39) | Retrospective | 294 | Cerebral (Cerebral Palsy) |
| Borowski, 2010 (S1) | Retrospective | 174 | Cerebral (Cerebral Palsy) |
| Borrini, 2014 (S2) | Prospective non-RCT | 158 | Multiple (Cerebral and Spinal) |
| Creamer, 2018 (27, S3) | RCT | 60 | Cerebral (Stroke) |
| Dvorak, 2010 (S4) | Retrospective | 167 | Multiple (Cerebral and Spinal) |
| Imerci, 2019 (40) | Retrospective | 341 | Cerebral (Cerebral Palsy) |
| Khan, 2010 (S5) | Retrospective | 40 | Spinal (Multiple Sclerosis) |
| Lee, 2018 (36) | Retrospective | 47 | Spinal (Multiple Sclerosis) |
| Morton, 2011 (S6) | Prospective non-RCT | 38 | Cerebral (Cerebral Palsy) |
| Motta, 2016 (38) | Retrospective | 508 | Multiple (Cerebral and Spinal) |
| Motta, 2014 (S7) | Retrospective | 430 | Multiple (Cerebral and Spinal) |
| Motta, 2011 (S8) | Retrospective | 30 | Cerebral (Cerebral Palsy) |
| Natale, 2012 (4, S9) | Prospective non-RCT | 112 | Multiple (Cerebral and Spinal) |
| Pucks-Faes, 2018 (37) | Retrospective | 116 | Multiple (Cerebral and Spinal) |
| Ramstad, 2010 (S10) | Prospective non-RCT | 38 | Cerebral (Cerebral Palsy) |
| Reis, 2019 (S11) | Retrospective | 155 | Multiple (Cerebral and Spinal) |
| Sammaraiee, 2020 (29) | Prospective non-RCT | 30 | Spinal (Multiple Sclerosis) |
| Sammaraiee, 2019 (7) | Prospective non-RCT | 106 | Spinal (Multiple Sclerosis) |
| Schiess, 2020 (1) | Prospective non-RCT | 1,743 | Multiple (Cerebral and Spinal) |
| Schiess, 2011 (28) | Prospective non-RCT | 30 | Cerebral (Stroke) |
| ITB Studies | |||
| Taira, 2013 (S12) | Retrospective | 400 | Multiple (Cerebral and Spinal) |
| Vles, 2013 (S13–S15) | RCT (through 6-month) then Prospective non-RCT | 17 | Cerebral (Cerebral Palsy) |
| Yoon, 2017 (34) | Prospective non-RCT | 37 | Cerebral (Cerebral Palsy and Brain Injury) |
| BoNT A Studies | |||
| Baricich, 2015 (32) | Retrospective | 26 | Cerebral (Stroke) |
| Chaleat-Valayer, 2011 (S16) | Prospective non-RCT | 282 | Cerebral (Cerebral Palsy) |
| Choi, 2019 (S17) | Retrospective | 591 | Cerebral (Cerebral Palsy) |
| Clemenzi, 2012 (S18) | Prospective non-RCT | 21 | Cerebral (Brain Injury) |
| Copeland, 2014 (S19) | RCT | 41 | Cerebral (Cerebral Palsy) |
| Delgado, 2017 (S20) | Prospective non-RCT (extension of a previous RCT) | 216 | Cerebral (Cerebral Palsy) |
| Demetrios, 2014 (S21) | Prospective non-RCT | 59 | Cerebral (Stroke) |
| Dressler, 2015 (33) | Prospective non-RCT | 54 | Multiple (Cerebral and Spinal) |
| Esquenazi, 2019 (17) | RCT | 468 | Cerebral (Stroke) |
| Fheodoroff, 2020 (12, 16, 20) | Prospective non-RCT | 155 | Cerebral (Cerebral Palsy, Stroke, Brain Injury, Brain Tumour, Cerebral Vascular Disorders) |
| Gonnade, 2018 (18) | RCT | 61 | Cerebral (Cerebral Palsy) |
| Hara, 2018 (13) | Retrospective | 35 | Cerebral (Stroke) |
| Hara, 2017 (31) | Retrospective | 51 | Cerebral (Stroke) |
| Ianieri, 2018 (S22) | Retrospective | 120 | Multiple (Cerebral and Spinal) |
| Intiso, 2014 (S23) | Prospective non-RCT | 22 | Cerebral (Cerebral Palsy and Brain Injury) |
| Invernizzi, 2015 (21) | Prospective non-RCT | 11 | Cerebral (Stroke) |
| Juneja, 2012 (S24) | Retrospective | 29 | Cerebral (Cerebral Palsy) |
| BoNT A Studies | |||
| Jung, 2011 (S25) | Prospective non-RCT | 27 | Cerebral (Cerebral Palsy) |
| Kerzoncuf, 2020 (S26) | RCT | 40 | Cerebral (Stroke) |
| Lannin, 2018 (S27) | Prospective non-RCT (feasibility randomized study) | 37 | Cerebral (Stroke) |
| Maanum, 2011 (S28) | RCT | 66 | Cerebral (Cerebral Palsy) |
| Roche, 2015 (S29) | RCT | 35 | Cerebral (Stroke) |
| Safer, 2016 (S30) | Prospective non-RCT | 24 | Cerebral (Cerebral Palsy) |
| Santamato, 2017 (S31) | Prospective non-RCT | 20 | Cerebral (Stroke) |
| Santamato, 2013 (S32) | Prospective non-RCT | 25 | Cerebral (Stroke) |
| Schramm, 2014 (S33) | Prospective non-RCT | 508 | Multiple (Cerebral and Spinal) |
| Unlu, 2010 (S34) | Retrospective | 71 | Cerebral (Cerebral Palsy) |
RCT: randomized controlled trial