TABLE 3.

Receiver operating characteristic (ROC) curve analysis for individual biomarkers.

Metabolite	AUC	T-tests	Log2 FC	Cutoff	Sensitivity	Specificity	LR +	LR-
L-Threonine	0.9149(0.862–0.964)	1.1775E-13	–0.5072	6760000	0.7083	0.9792	34.0	0.2979
3-Methyl-2-butene-1-thiol	0.8594(0.768–0.922)	2.0004E-8	–0.4731	5780000	0.625	0.9792	30.0	0.3830
N-Acetyl-leukotriene E4	0.9523(0.909–0.98)	1.836E-21	1.9233	501000	0.9792	0.7917	4.7	0.0263
4-Hydroxy-6-docosanone	0.8889(0.829–0.943)	2.0327E-10	0.5019	535000	0.6667	0.9792	32.0	0.3404
LysoPC(18:0)	0.9566(0.921–0.983)	6.3462E-18	0.6343	17900000	0.98	0.8	4.7	0.0263
Dehydrophytosphingosine	0.9267(0.873–0.969)	1.0436E-10	–3.779	270000	0.7292	0.9792	35.0	0.2766
9-cis-Retinoic acid	0.9557(0.916–0.985)	0.001197	–8.4275	101.865	0.875	0.875	7.0	0.1429

AUC, area under the curve; FC, fold change; LR, likelihood ratio.