TABLE 1.
HI and neutralization assay responses of H5N1 virus-infected individuals
| Serum | Sample | Responsea (antibody titer)
|
|||||
|---|---|---|---|---|---|---|---|
| HK/156 (H5N1)
|
A/SA (H3N2)
|
Dk/Sing (H5N3)
|
|||||
| HI | Neutralization | HI | Neutralization | HI | Neutralization | ||
| Humanb | |||||||
| A | S1 | <20 | 20 | <20 | 80 | <20 | 20 |
| S2 | <20 | 160 | <20 | 80 | <20 | 160 | |
| B | S1 | <20 | 10 | 160 | 640 | <20 | 10 |
| S2 | <20 | 80 | 80 | 1,280 | <20 | 40 | |
| C | S2 | 80 | 1,280 | 40 | 2,560 | 80 | 1,280 |
| D | S2 | <20 | 320 | <20 | 80 | <20 | 160 |
| E | S2 | 80 | 1,280 | 80 | 1,280 | 80 | 640 |
| H3 control-1 | S1 | <20 | 10 | 40 | 160 | <20 | 10 |
| S2 | <20 | 10 | 160 | 2,560 | <20 | 10 | |
| H3 control-2 | S1 | ND | ND | <20 | 40 | ND | ND |
| S2 | ND | ND | 80 | 640 | ND | ND | |
| Animalc | |||||||
| FαHK/156 | 160 | 1,600 | <10 | 100 | 640 | 3,200 | |
| FαA/SA | <10 | 100 | 640 | 1,600 | <10 | 100 | |
| FαDk/Sing | 80 | 400 | <10 | 100 | 160 | 800 | |
| N. Ferret | <10 | 100 | <10 | 100 | <10 | 100 | |
| GαTSA | 1,280 | 25,600 | <10 | 100 | 2,560 | 25,600 | |
| N. Goat | <10 | 100 | <10 | 100 | <10 | 100 | |
a
ND, not determined. Boldface indicates titer to homologous virus.
b
Serum samples from H5N1 or H3N2 virus-infected patients.
c
RDE-treated reference ferret (F) antisera generated against antigens A/Hong Kong/156/97 (H5N1), A/duck/Singapore-Q/F119-3/97 (H5N3), and A/South Africa/1147/95 (H3N2) and goat (G) antiserum to A/Tern/South Africa/61 (H5N2). Normal ferret and normal goat sera are represented by N. Ferret and N. Goat, respectively.