Table 1 |.

Mechanisms of FMRP regulation of ion channels

Channel/modulation	Direction of modulation by FMRP	Refs
Translational control
Kv1.2	⇧ or ⇩	58, 65, 95
Kv3.1	⇩	67, 68
Kv4.2	⇧ or ⇩	95–97
Slack	⇄ or ⇩	72, 95
BK	⇧	158
Cav1.3	⇧ or ⇩	88, 99
Cav2.1	⇧	89, 95
Cav2.3	⇩	90, 95
HCN	⇧ or ⇩	56, 57, 95, 102
AMPAR	⇧ or ⇩	59, 83, 104, 105
NMDAR	⇧ or ⇩	59, 111–113, 116
GABAAR	⇩	64, 119–125
Ion channel activity via FMRP-channel interactions
Slack	⇧	72
BK	⇧	57, 62, 80
SK	⇧ or ⇩	51, 86
Kv1.2	⇧	65
Kv4	⇩	91
Cav3	⇩	91
Ion channel surface expression via FMRP-channel interactions
Kv1.2	⇧	65
Cav2.1	⇧	60, 89
Cav2.2	⇩	60
HCN	⇧ or ⇩	102
AMPAR	⇧ or ⇩	59, 108
Second messenger pathways
INaP	⇩	52
Unidentified
NKCC1	⇩	145, 146

⇧ or ⇩, FMRP increases or decreases channel function, respectively;

⇄, no significant change in channel function;