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Models of protein nanoparticle-based SARS-CoV-2 vaccines. (a) 2D diagram of a receptor-binding domain (RBD)-coated protein nanoparticle vaccine. The RBD (green) is captured by the nanoparticle (gray) through the interactions between the SpyTag (orange) on the RBD and SpyCatcher (blue) on the nanoparticle. (b) 3D models of the nanoparticle coated by 60 copies of SARS-CoV-2 RBD or 20 copies of SARS-CoV-2 spike (S) trimer.
