FIGURE 1.

In vitro effect of montelukast on platelet-associated tissue factor (A) and P-selectin (B) expression induced by COVID-19 plasma. Whole blood (WB) from healthy subjects (HS; n = 4), pre-incubated with montelukast (0.01–1 µM), was plasma-depleted and reconstituted with COVID-19 plasma pools (n = 3 for each HS, dark gray bars) or autologous plasma (light gray bars). The percentage of TF^pos- and P-selectin^pos-platelets was assessed by flow cytometry. Data are reported as  mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001 (TF, tissue factor; Psel, P-selectin; PLT, platelets).