Table 1.
Characteristics of research participants at their most recent visits (age ≥ 45 years).
| Groups | Controls | Premutation carriers | P Values |
|---|---|---|---|
| Age: mean (SD) [N] | 63.6 (8.4) [82] | 66.6 (8.1) [175] | 0.008 |
| Intention tremor: % [N] | 21.4 [70] | 71.2 [170] | <0.001 |
| Cerebellar ataxia: % [N] | 10.0 [70] | 61.8 [170] | <0.001 |
| BDS: mean (SD) [N] | 22.1 (3.1) [68] | 18.3 (5.8) [166] | <0.001 |
| Psych. symptoms: mean (SD) [N] | 52.3 (11.2) [61] | 56.2 (11.3) [156] | 0.005 |
| Depression: mean (SD) [N] | 53.6 (11.1) [61] | 57.2 (11.9) [156] | 0.013 |
| MCP sign: % [N] | 0 [82] | 52.0 [175] | <0.001 |
| Pallidus T2-abnormalities: % [N] | 13.4 [82] | 25.1 [175] | 0.069 |
| With both signs of pallidus and MCP: % [N] |
0 [82] | 16.0 [175] | <0.001 |
| CGG repeat: mean (SD) [N] | 28.9 (4.6) [80] | 90.1 (20.3) [174] | <0.001 |
| FMR1 mRNA: mean (SD) [N] | 1.34 (0.39) [79] | 2.64 (0.80) [174] | <0.001 |
SD, standard deviation; BDS, Behavioral Dyscontrol Scale; MCP, middle cerebellar peduncle; FMR1, fragile X mental retardation 1.