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. 2022 Feb 22;17(2):e0263632. doi: 10.1371/journal.pone.0263632

Fig 4. Weighted gene correlation network representing gene expression in four brain regions of virgin female mice.

Fig 4

(A) The network, composed of genes expressed in Amygdala, Frontal Cortex, Hypothalamus, and Striatum of pup-exposed and non-exposed virgin controls, consists of 25 modules, each represented by clusters of different color and joined by lines representing positive (blue) or negative (red) eigengene correlations (in both cases showing only those correlations ≥0.6). Numbers have been added to label modules with particular enrichments in amygdala (A) DEGs as referred to in the text. (B-D) representations of the same network but showing the module membership of up- (blue dots) or down-regulated (red dots) DEGs identified in P1 v E18 (A-P1, B), P3 v E18 (A-P3, C), or P3vP1 (A-P3vP1, D) transcriptomic comparisons. Full details of network structure, membership and correlations are provided in S4 Table, with hypergeometric enrichments of genes within modules summarized in Tables 2 and S4E.