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. 2022 Feb 22;17(2):e0263632. doi: 10.1371/journal.pone.0263632

Fig 5. Dramatic changes in the amygdala chromatin landscape accompanies the transition to maternal-like behaviors in alloparenting virgin mice.

Fig 5

(A) Relative numbers of TSS-associated differentially enriched peaks (DAPs), as measured by >2-fold change in detected levels of H3K27Ac, in the four brain regions tested in this study. Positive numbers represent peaks more enriched at P3 than E18 (P3 DAPs); negative numbers represent less enriched (E18 DAPs) peaks. (B-E) Examples of DAPs in Drd1, Rarb1 (both up at P1 and then down-regulated at P3), Rora (down-regulated at P1 and P3 compared to E18), showing normalized H3K27Ac profiles in amygdala chromatin at E18 (A_E18, top track) and P3 (A_P3, bottom track) for each gene. Red arrows in each panel point to examples of significant differentially acetylated peaks. Full ChIP profiles are available online as a UCSC Browser track hub at https://trackhub.pnri.org/stubbs/ucsc/public/allo.html), and data are available in S5 and S6 Tables.