Table 3. Significant correlations between differential gene expression and differentially acetylated H3K27Ac peaks in amygdala with specific network modules.
| Amygdala DEGs/WGCNA module | p value | Amygala TSS-DAPs/WGCNA module | p value |
|---|---|---|---|
| AP1-up/module 3 | 6.3E-45 | E18_TSS-DAPs/module 3 | 4.9E-18 |
| AP1-up/module 7 | 2.2E-13 | E18_TSS-DAPs/module 6 | 1.6E-12 |
| AP1-up/module 8 | 1.3E-04 | E18_TSS-DAPs/module 2 | 5.6E-08 |
| AP1-down/module 6 | 4.0E-33 | E18_TSS-DAPs/module 4 | 7.2E-08 |
| AP1-down/module 4 | 3.0E-11 | E18_TSS-DAPs/module 20 | 2.0E-03 |
| AP1-down/module 20 | 4.8E-07 | E18_TSS-DAPs/module 8 | 1.0E-02 |
| AP3-up/module 15 | 1.8E-23 | P3_TSS-DAPs/module 8 | 4.5E-07 |
| AP3-up/module 1 | 1.8E-06 | P3_TSS-DAPs/module 7 | 4.2E-06 |
| AP3-up/module 25 | 8.9E-05 | P3_TSS-DAPs/module 24 | 1.0E-05 |
| AP3-down/module 6 | 2.2E-29 | P3_TSS-DAPs/module 15 | 3.3E-02 |
| AP3-down/module 19 | 8.6E-10 | ||
| AP3-down/module 16 | 3.8E-08 | ||
| AP3vP1-up/module 6 | 4.6E-06 | ||
| AP3vP1-up/module 6 | 1.7E-02 | ||
| AP3vP1-down/module 3 | 1.3E-22 | ||
| AP3vP1-down/module 6 | 5.9E-12 | ||
| AP3vP1-down/module 7 | 8.0E-03 |
Three top-scoring enrichments with hypergeometric p<0.05, of amygdala DEGs or all top-scoring TSS-DAP-associated genes into specific WGCNA modules, are listed for each DEG or DAP set. For a full list of comparisons of DEGs and DAPs in all brain regions to modules see S4E and S4F Table. AP1, DEGs at P1 compared to E18; AP3, DEGs at P3 compared to E18; AP3vP1, DEGs at P3 compared to P1. TSS-DAPs, DAPs located within 5 kb of a TSS of module-associated genes. E18_TSS-DAPs, peaks enriched in H3K27Ac at E18 compared to P3; P3_TSS-DAPs, peaks enriched at P3 compared to E18.