Table 2. Numbers of patients and results of statistical differences between non-severe and severe cases per waves.

	Wave 1			Wave 2			Wave 3			Total
	Non severe	Severe	p-value	Non severe	Severe	p-value	Non severe	Severe	p-value	Non severe	Severe	p-value
Nb patients	306 (71.33)	123 (28.67)		148 (69.16)	66 (30.84)		354 (81.76)	79 (18.24)		808 (75.09)	268 (24.91)
Nb deceases	0 (0.0)	70 (16.32)		0 (0.0)	42 (19.63)		0 (0.0)	28 (6.47)		0 (0.0)	140 (13.01)
Age	59.29 (±24.44)	71.12 (±17.2)	<0.01 **	60.9 (±23.58)	74.47 (±17.55)	<0.01 **	56.46 (±21.57)	62.08 (±18.73)	<0.05 *	58.34 (±23.1)	69.28 (±18.33)	<0.01 **
Gender (women)	151 (49.35)	47 (38.21)	<0.05 *	69 (46.62)	24 (36.36)	0.212	182 (51.41)	35 (44.3)	0.309	402 (49.75)	106 (39.55)	<0.01 **
Cancer	19 (6.21)	12 (9.76)	0.281	7 (4.73)	10 (15.15)	<0.05 *	12 (3.39)	5 (6.33)	0.37	38 (4.7)	27 (10.07)	<0.01 **
Diabetes	46 (15.03)	38 (30.89)	<0.01 **	21 (14.19)	17 (25.76)	0.064	42 (11.86)	13 (16.46)	0.357	109 (13.49)	68 (25.37)	<0.01 **
Embolism	7 (2.29)	3 (2.44)	0.795	1 (0.68)	0 (0.0)	0.678	11 (3.11)	3 (3.8)	0.97	19 (2.35)	6 (2.24)	0.898
Overweight or Obesity	50 (16.34)	28 (22.76)	0.155	21 (14.19)	8 (12.12)	0.848	43 (12.15)	25 (31.65)	<0.01 **	114 (14.11)	61 (22.76)	<0.01 **
Cardiovascular	102 (33.33)	41 (33.33)	1.0	35 (23.65)	21 (31.82)	0.277	59 (16.67)	31 (39.24)	<0.01 **	196 (24.26)	93 (34.7)	<0.01 **
Cirrhosis	0 (0.0)	1 (0.81)	0.637	0 (0.0)	0 (0.0)		1 (0.28)	0 (0.0)	0.41	1 (0.12)	1 (0.37)	0.998
Sickle Cell	1 (0.33)	0 (0.0)	0.637	1 (0.68)	0 (0.0)	0.678	1 (0.28)	0 (0.0)	0.41	3 (0.37)	0 (0.0)	0.741
IBD	2 (0.65)	0 (0.0)	0.908	0 (0.0)	0 (0.0)		1 (0.28)	0 (0.0)	0.41	3 (0.37)	0 (0.0)	0.741
Mental Retardation	3 (0.98)	4 (3.25)	0.208	0 (0.0)	0 (0.0)		2 (0.56)	0 (0.0)	0.804	5 (0.62)	4 (1.49)	0.33
Cognitive Impairment	16 (5.23)	8 (6.5)	0.774	3 (2.03)	3 (4.55)	0.56	5 (1.41)	3 (3.8)	0.336	24 (2.97)	14 (5.22)	0.123
Pregnancy	23 (7.52)	1 (0.81)	<0.05 *	10 (6.76)	3 (4.55)	0.752	26 (7.34)	11 (13.92)	0.095	59 (7.3)	15 (5.6)	0.414
Trisomy	0 (0.0)	1 (0.81)	0.637	0 (0.0)	0 (0.0)		1 (0.28)	0 (0.0)	0.41	1 (0.12)	1 (0.37)	0.998
Heart Failure	11 (3.59)	6 (4.88)	0.732	1 (0.68)	4 (6.06)	0.055	10 (2.82)	4 (5.06)	0.506	22 (2.72)	14 (5.22)	0.076
Dementia	0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)
Psychiatric Disorders	0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)
Pulmonary problems	33 (10.78)	14 (11.38)	0.993	9 (6.08)	6 (9.09)	0.612	25 (7.06)	11 (13.92)	0.076	67 (8.29)	31 (11.57)	0.136
Organ Transplant	0 (0.0)	1 (0.81)	0.637	0 (0.0)	1 (1.52)	0.678	2 (0.56)	0 (0.0)	0.804	2 (0.25)	2 (0.75)	0.56
Stroke Sequelae	5 (1.63)	0 (0.0)	0.353	2 (1.35)	0 (0.0)	0.857	3 (0.85)	0 (0.0)	0.943	10 (1.24)	0 (0.0)	0.144

Results are presented with mean and standard deviation for age which is a quantitative feature, and numbers and proportion for the rest since they all are binary qualitative features. A blank space for p-value means that there was no patient with the particular comorbidity in the wave, so that the Chi-square test could not be performed.

For visual help for p-value, a single star (*) denotes a p-value strictly inferior than 0.05 and two stars (**) denotes a p-value strictly inferior than 0.01.