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. 2022 Feb 22;17(2):e0263266. doi: 10.1371/journal.pone.0263266

Table 2. Numbers of patients and results of statistical differences between non-severe and severe cases per waves.

Wave 1 Wave 2 Wave 3 Total
Non severe Severe p-value Non severe Severe p-value Non severe Severe p-value Non severe Severe p-value
Nb patients 306 (71.33) 123 (28.67) 148 (69.16) 66 (30.84) 354 (81.76) 79 (18.24) 808 (75.09) 268 (24.91)
Nb deceases 0 (0.0) 70 (16.32) 0 (0.0) 42 (19.63) 0 (0.0) 28 (6.47) 0 (0.0) 140 (13.01)
Age 59.29 (±24.44) 71.12 (±17.2) <0.01 ** 60.9 (±23.58) 74.47 (±17.55) <0.01 ** 56.46 (±21.57) 62.08 (±18.73) <0.05 * 58.34 (±23.1) 69.28 (±18.33) <0.01 **
Gender (women) 151 (49.35) 47 (38.21) <0.05 * 69 (46.62) 24 (36.36) 0.212 182 (51.41) 35 (44.3) 0.309 402 (49.75) 106 (39.55) <0.01 **
Cancer 19 (6.21) 12 (9.76) 0.281 7 (4.73) 10 (15.15) <0.05 * 12 (3.39) 5 (6.33) 0.37 38 (4.7) 27 (10.07) <0.01 **
Diabetes 46 (15.03) 38 (30.89) <0.01 ** 21 (14.19) 17 (25.76) 0.064 42 (11.86) 13 (16.46) 0.357 109 (13.49) 68 (25.37) <0.01 **
Embolism 7 (2.29) 3 (2.44) 0.795 1 (0.68) 0 (0.0) 0.678 11 (3.11) 3 (3.8) 0.97 19 (2.35) 6 (2.24) 0.898
Overweight or Obesity 50 (16.34) 28 (22.76) 0.155 21 (14.19) 8 (12.12) 0.848 43 (12.15) 25 (31.65) <0.01 ** 114 (14.11) 61 (22.76) <0.01 **
Cardiovascular 102 (33.33) 41 (33.33) 1.0 35 (23.65) 21 (31.82) 0.277 59 (16.67) 31 (39.24) <0.01 ** 196 (24.26) 93 (34.7) <0.01 **
Cirrhosis 0 (0.0) 1 (0.81) 0.637 0 (0.0) 0 (0.0) 1 (0.28) 0 (0.0) 0.41 1 (0.12) 1 (0.37) 0.998
Sickle Cell 1 (0.33) 0 (0.0) 0.637 1 (0.68) 0 (0.0) 0.678 1 (0.28) 0 (0.0) 0.41 3 (0.37) 0 (0.0) 0.741
IBD 2 (0.65) 0 (0.0) 0.908 0 (0.0) 0 (0.0) 1 (0.28) 0 (0.0) 0.41 3 (0.37) 0 (0.0) 0.741
Mental Retardation 3 (0.98) 4 (3.25) 0.208 0 (0.0) 0 (0.0) 2 (0.56) 0 (0.0) 0.804 5 (0.62) 4 (1.49) 0.33
Cognitive Impairment 16 (5.23) 8 (6.5) 0.774 3 (2.03) 3 (4.55) 0.56 5 (1.41) 3 (3.8) 0.336 24 (2.97) 14 (5.22) 0.123
Pregnancy 23 (7.52) 1 (0.81) <0.05 * 10 (6.76) 3 (4.55) 0.752 26 (7.34) 11 (13.92) 0.095 59 (7.3) 15 (5.6) 0.414
Trisomy 0 (0.0) 1 (0.81) 0.637 0 (0.0) 0 (0.0) 1 (0.28) 0 (0.0) 0.41 1 (0.12) 1 (0.37) 0.998
Heart Failure 11 (3.59) 6 (4.88) 0.732 1 (0.68) 4 (6.06) 0.055 10 (2.82) 4 (5.06) 0.506 22 (2.72) 14 (5.22) 0.076
Dementia 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)
Psychiatric Disorders 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)
Pulmonary problems 33 (10.78) 14 (11.38) 0.993 9 (6.08) 6 (9.09) 0.612 25 (7.06) 11 (13.92) 0.076 67 (8.29) 31 (11.57) 0.136
Organ Transplant 0 (0.0) 1 (0.81) 0.637 0 (0.0) 1 (1.52) 0.678 2 (0.56) 0 (0.0) 0.804 2 (0.25) 2 (0.75) 0.56
Stroke Sequelae 5 (1.63) 0 (0.0) 0.353 2 (1.35) 0 (0.0) 0.857 3 (0.85) 0 (0.0) 0.943 10 (1.24) 0 (0.0) 0.144

Results are presented with mean and standard deviation for age which is a quantitative feature, and numbers and proportion for the rest since they all are binary qualitative features. A blank space for p-value means that there was no patient with the particular comorbidity in the wave, so that the Chi-square test could not be performed.

For visual help for p-value, a single star (*) denotes a p-value strictly inferior than 0.05 and two stars (**) denotes a p-value strictly inferior than 0.01.