a. Serum IgM Antibodies levels in a subgroup of patients from 1 to 25. Serum IgM Antibodies levels in a subgroup of patients from 1 to 25 at baseline (T0; blue line), month 3 (T3; orange line), month 6 (T6; grey line), month 12 (T12; yellow line). b. Serum IgM Antibodies levels in a subgroup of patients from 26 to 50. Serum IgM Antibodies levels in a subgroup of patients from 26 to 50 at baseline (T0; blue line), month 3 (T3; orange line), month 6 (T6; grey line), month 12 (T12; yellow line). c. Serum IgM Antibodies levels in a subgroup of patients from 51 to 75. Serum IgM Antibodies levels in a subgroup of patients from 51 to 75 at baseline (T0; blue line), month 3 (T3; orange line), month 6 (T6; grey line), month 12 (T12; yellow line).