Table 1. Numbers of patients analysed and (in parentheses) risk per 100,000 people for the whole population during follow-up of venous and arterial events and TCP.
| Overall | |||||
|---|---|---|---|---|---|
| All | Venous | Arterial | TCP | ||
| N | 46,162,942 | 20,903 (45.3) | 87,251 (189) | 1,926 (4.2) | |
| Sex | Male | 22,765,779 | 10,358 (45.5) | 51,851 (228) | 986 (4.3) |
| Female | 23,397,163 | 10,545 (45.1) | 35,400 (151) | 940 (4.0) | |
| Age | 18–29 | 8,821,973 | 781 (8.9) | 400 (4.5) | 143 (1.6) |
| 30–49 | 16,131,025 | 3,544 (22.0) | 6,424 (39.8) | 338 (2.1) | |
| 50–69 | 13,791,173 | 7,510 (54.5) | 31,459 (228) | 686 (5.0) | |
| 70–79 | 4,674,973 | 4,820 (103) | 22,249 (476) | 418 (8.9) | |
| 80+ | 2,743,798 | 4,248 (155) | 26,719 (974) | 341 (12.4) | |
| Ethnicity | Asian or Asian British | 3,718,442 | 599 (16.1) | 5,325 (143) | 152 (4.1) |
| Black or Black British | 1,634,470 | 654 (40.0) | 2,086 (128) | 58 (3.5) | |
| Mixed | 712,534 | 182 (25.5) | 642 (90.1) | 22 (3.1) | |
| Other ethnic groups | 1,497,133 | 217 (14.5) | 1,072 (71.6) | 39 (2.6) | |
| White | 36,446,855 | 18,995 (52.1) | 77,118 (212) | 1,643 (4.5) | |
| Unknown or missing | 2,153,508 | 256 (11.9) | 1,008 (46.8) | 12 (0.6) | |
| Deprivation1 | 1–2 | 9,118,746 | 4,565 (50.1) | 18,830 (206) | 365 (4.0) |
| 3–4 | 9,567,633 | 4,105 (42.9) | 17,436 (182) | 370 (3.9) | |
| 5–6 | 9,355,549 | 4,091 (43.7) | 17,642 (189) | 392 (4.2) | |
| 7–8 | 9,076,313 | 4,146 (45.7) | 16,939 (187) | 381 (4.2) | |
| 9–10 | 8,772,902 | 3,926 (44.8) | 16,024 (183) | 406 (4.6) | |
| Smoking status | Current | 7,814,045 | 3,079 (39.4) | 16,115 (206) | 260 (3.3) |
| Former | 10,623,072 | 6,930 (65.2) | 31,768 (299) | 581 (5.5) | |
| Never | 25,722,494 | 10,667 (41.5) | 38,701 (150) | 1,053 (4.1) | |
| Medical history | Stroke | 727,218 | 1,020 (140) | 21,489 (2,955) | 104 (14.3) |
| MI | 1,189,182 | 1,436 (121) | 24,212 (2,036) | 158 (13.3) | |
| DVT or PE | 603,351 | 3,263 (541) | 4,050 (671) | 142 (23.5) | |
| Thrombophilia | 44,593 | 146 (327) | 202 (453) | 23 (51.6) | |
| Coronavirus infection2 | 1,284,984 | 1,131 (88.0) | 4,167 (324) | 101 (7.9) | |
| Diabetes | 4,069,412 | 3,654 (89.8) | 25,595 (629) | 423 (10.4) | |
| Depression | 9,516,020 | 6,272 (65.9) | 24,146 (254) | 500 (5.3) | |
| Obesity | 10,918,274 | 8,863 (81.2) | 31,194 (286) | 679 (6.2) | |
| Cancer | 6,609,691 | 5,674 (85.8) | 17,827 (270) | 786 (11.9) | |
| COPD | 1,582,366 | 2,497 (158) | 12,323 (779) | 182 (11.5) | |
| Liver disease | 230,243 | 284 (123) | 1,069 (464) | 97 (42.1) | |
| CKD | 2,934,107 | 4,467 (152) | 25,816 (880) | 526 (17.9) | |
| Major surgery3 | 3,995,870 | 5,407 (135) | 24,164 (605) | 763 (19.1) | |
| Dementia | 524,293 | 1,127 (215) | 6,073 (1,158) | 45 (8.6) | |
| Medications | Antiplatelet | 2,510,382 | 2,814 (112) | 36,415 (1,451) | 218 (8.7) |
| BP lowering | 8,589,860 | 7,969 (92.8) | 55,462 (646) | 777 (9.0) | |
| Lipid lowering | 6,808,408 | 5,796 (85.1) | 47,859 (703) | 564 (8.3) | |
| Anticoagulant | 1,338,585 | 2,278 (170) | 12,758 (953) | 205 (15.3) | |
| Oral contraceptive | 622,529 | 138 (22.2) | 42 (6.7) | 8 (1.3) | |
| HRT | 540,722 | 213 (39.4) | 516 (95.4) | 16 (3.0) | |
| Number of diagnoses | 0 | 36,455,307 | 12,200 (33.5) | 38,617 (106) | 980 (2.7) |
| 1–5 | 9,573,068 | 8,422 (88.0) | 46,012 (481) | 925 (9.7) | |
| 6+ | 134,567 | 281 (209) | 2,622 (1948) | 21 (15.6) | |
| Number of medications | 0 | 22,970,920 | 3,679 (16.0) | 9,629 (41.9) | 321 (1.4) |
| 1–5 | 20,875,516 | 12,872 (61.7) | 56,255 (269) | 1,210 (5.8) | |
| 6+ | 2,316,506 | 4,352 (188) | 21,367 (922) | 395 (17.1) | |
1Index of Multiple Deprivation deciles where 10 indicates least deprived and 1 indicates most deprived.
2After 31 December 2019 and prior to 8 December 2020.
3In the last year.
BP, blood pressure; CKD, chronic kidney disease; COPD, chronic obstructive respiratory disease; DVT, deep vein thrombosis; HRT, hormone replacement therapy; MI, myocardial infarction; PE, pulmonary embolism; TCP, thrombocytopenia.