Table 2.
Distributions of lncRNA GAS5 Genotypic and Allelic Frequencies Among RCC Patients and Controls
| Genotypes | RCC Patients n=624(%) |
Controls n=655(%) |
AOR(95% CI) | P value | P value* |
|---|---|---|---|---|---|
| rs145204276 | |||||
| ins/ins(II) | 349(55.9) | 301(46.0) | 1.8×10−3 | 4.8×10−3 | |
| ins/del(ID) | 231(37.0) | 289(44.1) | |||
| del/del(DD) | 44(7.1) | 65(9.9) | |||
| Dominant model II vs ID/DD | 275(44.1) | 354(54.0) | 0.67(0.54–0.84) | 4.5×10−4 | 1.8×10−3 |
| Recessive model II/ID vs DD | 580(92.9) | 590(90.1) | 1.45(0.97–2.17) | 0.066 | 0.13 |
| I allele | 929(74.4) | 891(68.0) | |||
| D allele | 319(25.6) | 419(32.0) | 0.73(0.61–0.87) | 3.4×10−4 | 1.8×10−3 |
| rs55829688 | |||||
| TT | 322(51.6) | 308(47.0) | 0.26 | 0.30 | |
| TC | 246(39.4) | 282(43.1) | |||
| CC | 56(9.0) | 65(9.9) | |||
| Dominant model TT vs TC/CC | 302(48.4) | 347(53.0) | 0.83(0.67–1.04) | 0.10 | 0.16 |
| Recessive model TT/TC vs CC | 568(91.0) | 590(90.1) | 1.12 (0.77–1.63) | 0.56 | 0.56 |
| T allele | 890(71.3) | 898(68.5) | |||
| C allele | 358(28.7) | 412(31.5) | 0.88(0.74–1.04) | 0.13 | 0.17 |
Notes: P value of difference in genotypes between case group and control group. Adjusted for age, sex, BMI, smoking status and drinking status. *False discovery rate-adjusted P value for multiple hypotheses testing using the Benjamini-Hochberg method. P < 0.05 is indicated in bold font.
Abbreviations: RCC, renal cell carcinoma; II, ins/ins; ID, ins/del; DD, del/del; CI, confidence interval; OR, odds ratio.