Table 4.
Stratified Analysis Between the Genotypes and Alleles of lncRNA GAS5 rs55829688 Polymorphism Among RCC Patients and Control Group
| Characteristics | RCC Patients Group | Control Group | P value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype n (%) | Allele n (%) | Genotype n (%) | Allele n (%) | |||||||||||
| TT | TC | CC | T | C | TT | TC | CC | T | C | PG | PG* | PA | PA* | |
| Age | ||||||||||||||
| < 60 | 182(50.8) | 140(39.1) | 36(10.1) | 504(70.4) | 212(29.6) | 174(47.0) | 158(42.7) | 38(10.3) | 506(68.4) | 234(31.6) | 0.57 | 0.70 | 0.43 | 0.48 |
| ≥ 60 | 140(52.7) | 106(39.8) | 20(7.5) | 386(72.6) | 146(27.4) | 134(47.0) | 124(43.5) | 27(9.5) | 392(68.8) | 178(31.2) | 0.40 | 0.70 | 0.19 | 0.48 |
| Gender | ||||||||||||||
| Male | 200(50.9) | 158(40.2) | 35(8.9) | 558(71.0) | 228(29.0) | 197(47.2) | 179(42.9) | 41(9.8) | 573(68.7) | 261(31.3) | 0.59 | 0.70 | 0.33 | 0.48 |
| Female | 122(52.8) | 88(38.1) | 21(9.1) | 332(71.9) | 130(28.1) | 111(46.6) | 103(43.3) | 24(10.1) | 325(68.3) | 151(31.7) | 0.41 | 0.70 | 0.25 | 0.48 |
| BMI | ||||||||||||||
| < 24 | 145(50.9) | 115(40.2) | 25(8.8) | 405(71.1) | 165(28.9) | 147(47.3) | 132(42.4) | 32(10.3) | 426(68.5) | 196(31.5) | 0.63 | 0.70 | 0.34 | 0.48 |
| ≥ 24 | 177(52.2) | 131(38.6) | 31(9.2) | 485(71.5) | 193(28.5) | 161(46.8) | 150(43.6) | 33(9.6) | 472(68.6) | 216(31.4) | 0.35 | 0.70 | 0.24 | 0.48 |
| Smoking | ||||||||||||||
| Yes | 124(50.0) | 103(41.5) | 21(8.5) | 351(70.8) | 145(29.2) | 99(43.6) | 103(45.4) | 25(11.0) | 301(66.3) | 153(33.7) | 0.33 | 0.70 | 0.14 | 0.48 |
| No | 198(52.7) | 143(38.0) | 35(9.3) | 539(71.7) | 213(28.3) | 209(48.9) | 179(41.8) | 40(9.3) | 597(69.7) | 259(30.3) | 0.52 | 0.70 | 0.41 | 0.48 |
| Drinking | ||||||||||||||
| Yes | 87(50.6) | 70(40.7) | 15(8.7) | 244(70.9) | 100(29.1) | 74(46.8) | 68(43.0) | 16(10.2) | 216(68.4) | 100(31.6) | 0.77 | 0.77 | 0.50 | 0.50 |
| No | 235(52.0) | 176(38.9) | 41(9.1) | 646(71.5) | 258(28.5) | 234(47.1) | 214(43.1) | 49(9.8) | 682(68.6) | 312(31.4) | 0.32 | 0.70 | 0.19 | 0.48 |
Notes: PG: p value of difference in genotypes between case group and control group; PA: p value of difference in alleles between case group and control group. Adjusted for age, sex, BMI, smoking status and drinking status. *False discovery rate-adjusted P value for multiple hypotheses testing using the Benjamini-Hochberg method.
Abbreviation: RCC, renal cell carcinoma.