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(A) H&E, PCNA, and TUNEL staining in the tumor regions of mice in each group after different treatments. (B) Corresponding TUNEL apoptosis index and (C) PCNA proliferation index in the different groups. (D) H&E staining of major organs (heart, liver, spleen, lung, and kidney) in each group after treatments (*p<.05, **p<.01). H&E: hematoxylin and eosin; PCNA: proliferating cell nuclear antigen; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling.
