Table 1.
Demographic and Clinicopathologic Characteristics of 56 Patients Who Underwent Resection of ICC and 89 Patients with Unresectable ICC
| Characteristic | Surgical cohort (n=56) | Medical cohort (n=89) | P value |
|---|---|---|---|
| Patient factors | |||
| Age, mean (SD), yr | 61.0 (11.0) | 60.6 (11.7) | .646 |
| Sex, n (%) | |||
| Male | 18 (32) | 45 (50) | .029 |
| Female | 38 (68) | 44 (50) | |
| Tumor clinical factors | |||
| CA19–9 level at diagnosis, mean (SD), U/mL | 629.4 (2570.9) | 5470.7 (18826.8) | .002 |
| CA19–9 >37 U/mL, n (%) | 26 (46) | 54 (61) | .093 |
| Neoadjuvant chemotherapy, n (%) | 19 (34) | - | - |
| Number of cycles, mean (SD) | 6.7 (3.4) | - | - |
| Partial response, n (%) | 8 (42) | - | - |
| Adjuvant chemotherapy, n (%) | 40 (71) | - | - |
| History of viral hepatitis, n (%)a | 5 (13) | 8 (19) | .474 |
| Tumor histopathologic factors | |||
| Poorly differentiated tumor, n (%) | 23 (41) | 36 (51) | .247 |
| Maximum tumor size, median (SD), cm | 6.1 (2.3) | 10.8 (3.8)b | <.001 |
| Multiple tumors, n (%) | 8 (14) | 56 (63)b | <.001 |
| Number of tumors, mean (SD) | 6.9 (12.9) | 11.2 (18.0)b | <.001 |
| Positive lymph nodes, n (%)c | 7 (33) | - | - |
| T category ≥3, n (%) | 12 (21) | - | - |
| R1 surgical margin, n (%) | 15 (27) | - | - |
| Cirrhosis, n (%) | 3 (5) | - | - |
| Arterial enhancement pattern | |||
| Hypervascular, n (%) | 17 (30) | 13 (15) | .023 |
| Peripherally enhancing, n (%) | 29 (52) | 43 (48) | .684 |
| Hypovascular, n (%) | 10 (18) | 33 (37) | <.001 |
| Tumor density, mean (SD), HU | 84.3 (36.4) | 63.9 (21.5) | <.001 |
| Tumor/liver density ratio, mean (SD) | 1.18 (0.5) | 0.85 (0.3) | .002 |
Abbreviations: CA19–9, carbohydrate antigen 19–9; HU, Hounsfield unit; ICC, intrahepatic cholangiocarcinoma; SD, standard deviation.
a
Data on viral hepatitis were unavailable for 17 patients in the surgical cohort and 46 patients in the medical cohort.
b
Radiologic data.
c
Data on lymph node status were unavailable for 35 patients who did not undergo lymphadenectomy.